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Indicated for management of mild-to-moderate pain and moderate-to-severe pain alone or in combination with opioid analgesics. To reduce the risk of renal adverse reactions, patients must be well hydrated prior to IV administration.
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Common side effects include abdominal pain, gastrointestinal bleeding, nausea, dizziness, headache, and swelling. Diclofenac was patented in by Ciba-Geigy ; it came into medical use in the United States in In many countries, eye drops are sold to treat acute and chronic nonbacterial inflammation of the anterior part of the eyes e. Diclofenac eye drops have also been used to manage pain for traumatic corneal abrasion. In, a study found major vascular events were increased by about a third by diclofenac, chiefly due to an increase in major coronary events.
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In patients with systemic lupus erythematosus SLE and mixed connective tissue disorders there may be an increased risk of aseptic meningitis see section 4. Activated charcoal may be considered after ingestion of a potentially toxic overdose, and gastric decontamination e. The tablets should be swallowed whole with liquid, preferably before meals, and must not be chewed or divided.
Voltarol should be discontinued at the first appearance of skin rash, mucosal lesions or any other signs of hypersensitivity. NSAIDs, including diclofenac, may be associated with increased risk of gastro-intestinal anastomotic leak. Patients should remain alert for the signs and symptoms of serious arteriothrombotic events e. As with all NSAIDs, including diclofenac, close medical surveillance is imperative and particular caution should be exercised when prescribing diclofenac in patients with symptoms indicative of gastrointestinal disorders, or with a history suggestive of gastric or intestinal ulceration, bleeding or perforation see section 4.
If abnormal liver function tests persist or worsen, clinical signs or symptoms consistent with liver disease develop or if other manifestations occur eosinophilia, rash, Voltarol should be discontinued. If needed, further doses of 50 mg may be taken at intervals of hours, not exceeding a total dose of mg per day.
Undesirable effects may be minimised by using the lowest effective dose for the shortest duration necessary to control symptoms see section 4. Monitoring of renal function is recommended as a precautionary measure when using diclofenac in such cases. Monitoring of the serum digoxin level is recommended. Patients with defects of haemostasis, bleeding diathesis or haematological abnormalities should be carefully monitored. Acute renal failure, haematuria, proteinuria, nephrotic syndrome, interstitial nephritis, renal papillary necrosis.
The buy voltarol 50 mg of the dose is eliminated as metabolites through the bile in the faeces. Thrombocytopenia, leucopoenia, anaemia including haemolytic and aplastic anaemia, agranulocytosis. Close medical surveillance and caution are recommended when using diclofenac after gastro-intestinal surgery. There is no typical clinical picture resulting from diclofenac over dosage.
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