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Multidisciplinary Respiratory Medicine volume 14, Article number: 40 Cite this article. They are used to treat symptoms that are secondary to histamine release, which is typical of certain allergic conditions, including rhinitis, conjunctivitis, asthma, urticaria, and anaphylaxis. In these years, a remarkable body of evidence has been built. Histamine is the pivotal mediator of an allergic reaction. The concentration of histamine is particularly high in mast cells, that reside in the respiratory tree, gastrointestinal tract, and skin. Histamine can act on four types of receptors: H1, H2, H3, and H4. H1 and H2 receptors are distributed in both the peripheral and the central nervous system Cost of vantin and allow histamine to exert effects on smooth muscles and glands. By acting on H1, histamine causes itching, stimulates secretion from the nasal mucosa, contracts smooth muscle in the bronchi and intestines, and relaxes smooth muscle in small blood vessels.
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