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Trihexyphenidyl is an antispasmodic drug which exerts a direct inhibitory effect on the parasympathetic nervous system. It also has a relaxing effect on smooth muscle. Trihexyphenidyl is effective in reducing the rigidity of muscle spasm, tremor and excessive salivation associated with Parkinsonism. Trihexyphenidyl is also indicated to control extrapyramidal disorders eg akathisia manifested by extreme restlessness and dyskinesia characterised by spastic contractions and involuntary movements due to central nervous system buys trihexyphenidyl such as reserpine and the phenothiazines. The usual dosage for Parkinsonism is mg per day although some patients chiefly in the post-encephalitic group may require an average total dose of mg daily. It should be given orally either three or four times a day at mealtimes.
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