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Parent drugs and metabolites may cross-react with TCA immunoassay even at therapeutic concentration. Free phenytoin concentrations were 6. Plasma concentrations are lower in pregnant than in non-pregnant women. Another drug that must be considered for cross-reactivity with phenytoin assays is fosphenytoin 5,5-diphenyl-2,4-imidazolidine-dione disodium salt. Phenytoin may reduce the efficacy of hormonal contraceptives.

Phenytoin is metabolized to nontoxic metabolites by the liver. Cetirizine is a metabolite of hydroxyzine, and cetirizine is also used as antihistamine. At high concentrations, these enzymes become saturated, and the half-life may increase to several days as elimination kinetics change from first order to zero order. It has been used for the treatment of eclampsia Friedman For this reason, it is also used as an antiarrhythmic. The half-life of phenytoin varies considerably, from 20 to 50 hours.

Thus dosing is frequently adjusted to target a blood level in the goal range and is rarely continued beyond the acute period. Phenytoin Phenytoin is an effective anticonvulsant against tonic-clonic and partial seizures and an important pharmacologic tool that has increased understanding of the underlying mechanisms responsible for epileptic syndromes.

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Phenytoin belongs to the group of medications known as anti-epileptics. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor. Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.