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It is commonly referred to in the clinical and pharmacological literature as l-deprenyl. Each capsule contains 5 mg selegiline hydrochloride, USP. Inactive ingredients are anhydrous citric acid, lactose, magnesium stearate, and microcrystalline cellulose. Inhibition of monoamine oxidase, type B, activity is generally considered to be of primary importance; in addition, there is evidence that selegiline may act through other mechanisms to increase dopaminergic activity. Selegiline is best known as an irreversible inhibitor of monoamine oxidase MAO, an intracellular enzyme associated with the outer membrane of mitochondria.
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As your symptoms improve and your body movements become easier, be careful not to overdo physical activities. Do not stop taking this medicine without speaking with your doctor first - stopping suddenly can cause problems. When it is prescribed with other medicines, selegiline helps to prevent some of the problems which can occur with these other treatments. These problems may be referred to as 'end-of-dose' fluctuations, or 'on-off' symptoms.
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It does not cure Parkinson's disease, but it may improve shakiness order eldepryl drug, muscle stiffness, loss of normal movement as your dose of other Parkinson's medication wears off end-of-dose failure, and sudden switching between normal movement and stiffness on-off problems. It may improve your range of motion and ability to walk, dress, and exercise. Taking selegiline late in the day may cause trouble sleeping. Dosage is based on your medical condition and response to therapy. The usual highest dose is 5 milligrams twice a day.
An alternative MAO-B inhibitor, rasagiline, may be a suitable agent for new patients or those transitioning from selegiline. This resource provides advice on prescribing and supplying rasagiline, which is currently funded but not yet approved by Medsafe. The transition from selegiline to alternative treatment 4. Switching from selegiline to rasagiline: How do they compare?
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The manufacturer of deprenyl selegeline; Eldepryl Somerset Pharmaceuticals, Tampa, FL recently advised physicians to avoid prescribing the drug in combination with an antidepressant because of potentially serious CNS toxicity that may represent the serotonin syndrome. Manifestations of the serotonin syndrome vary but may include changes in mental status and motor and autonomic function.
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Last edited on September 20, Cytochrome P Metabolism. See also article: Introduction to Pharmacology.
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Selegiline acts as a monoamine oxidase order eldepryl drug, and increases levels of monoamine neurotransmitters in the brain. At typical clinical doses, selegiline is a selective and irreversible inhibitor of monoamine oxidase B MAO-B, increasing levels of dopamine in the brain. In larger doses, it loses its specificity and also inhibits MAO-A, increasing levels of serotonin, norepinephrine, and dopamine in the brain. Some studies have found selegiline to be just as effective as methylphenidate in treating attention deficit hyperactivity disorder ADHD in both children and adults but with less side effects, especially appetite suppression, anxiety, headaches and sleep disturbances.
Authored by Dr. Aftab H Patni, MD
