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Donepezil is a cholinesterase inhibitor that is commonly used to ameliorate the symptoms of Alzheimer disease 1.
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Rhabdomyolysis is a rare condition involving the breakdown of muscle tissue. Rhabdomyolysis can cause serious and sometimes fatal abnormal heart rhythms, kidney damage and kidney failure, but is generally treatable if recognized promptly. NMS is a very rare life-threatening disorder characterized by a chemical imbalance that affects the nervous, muscular and cardiovascular systems. The muscular effects of NMS can sometimes lead to rhabdomyolysis. Symptoms of NMS include high fever, muscle stiffness or rigidity, mental changes including delirium and agitation, and irregular heartbeat and pulse.