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The main objective of this study was to characterize the population pharmacokinetics of tamsulosin hydrochloride HCl in paediatric patients with neuropathic and non-neuropathic bladder. A secondary objective was to compare the pharmacokinetics in paediatric patients and adults. Tamsulosin HCl plasma concentrations in plasma samples from paediatric patients age range 2—16 years were analyzed with NONMEM, applying a one compartment model with first-order absorption. Based on the principles of allometry, body weight was incorporated in the base model, along with fixed allometric exponents. Simulations based on the final model were used to compare the pharmacokinetics with those in adults. The results of simulations indicated that the exposure in After a weight-based dose administration, the exposure in paediatric patients was comparable with that in healthy adults.

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