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Alloantigens can be recognized by T cells either by direct or indirect way and trigger a T cell immune response. Naive lymphocyte migrates to lymph node after sensitization and differentiates into an effector cells that migrate back to the graft in order to induce rejection. In addition to alloantigen recognition by T lymphocyte, costimulatory molecules such as B also activate proliferation of lymphocytes. It has been a challenging task to prevent the rejection of allograft in a recipient.

An important area of research in the field of immunology is to avoid the rejection of an allograft and allow it to survive without any immune reactivity. Some antimetabolites that have the potential to kill the activating T lymphocyte can be used to prevent the alloreactive response. Inhibition of costimulatory molecule is another strategy to prevent the rejection of the allograft.

Anti-inflammatory drugs such as corticosteroids are frequently used to create an immunosuppressive condition in an individual and allow the survival of graft. Transplantation of organs from pigs to human is an interesting outcome of the transplantation immunology. Pigs are preferred species for transplantation in human as compared to other species because of the anatomical compatibilities.

However, the presence of natural antibodies such as IgM to the xenograft causes a hyperacute reaction in the recipients. The natural antibodies are mostly directed towards the carbohydrate present over the cell surface. Xenograft can also be rejected by T cell mediated immune responses similar to what is observed for the allograft. The concept of blood grouping was put forth by Karl Landsteiner, who divided the blood into A, B, and O based on the presence of specific antigens.

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