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Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients in short-term studies. Closely monitor all antidepressant-treated patients for clinical worsening and for emergence of suicidal thoughts and behaviors. Mirtazapine is not approved for use in pediatric patients. Panic disorder alternative agent off-label use Oral: Initial: 15 mg once daily at bedtime; may increase in synthroid 0.05 mg of 15 mg at intervals of no less than 1 week based on response and tolerability, up to a usual maximum of 45 mg once daily Ref. Reasons for a slower taper eg, over 4 weeks include prior history of antidepressant withdrawal symptoms or high doses of antidepressants Ref.

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Mirtazapine is a presynaptic alpha 2 -adrenoreceptor antagonist which increases central noradrenergic and serotonergic neurotransmission. Anxiety; appetite increased; arthralgia; back pain; confusion; constipation; diarrhoea; dizziness; drowsiness; dry mouth; fatigue; headache on discontinuation ; myalgia; nausea; oedema; postural hypotension; sleep disorders; tremor; vomiting; weight increased. Agranulocytosis; arrhythmias; bone marrow disorders; dysarthria; eosinophilia; granulocytopenia; hyponatraemia; jaundice discontinue ; QT interval prolongation; rhabdomyolysis; seizure; serotonin syndrome; severe cutaneous adverse reactions SCARs ; SIADH; skin reactions; sudden death; suicidal behaviours; thrombocytopenia; urinary retention; withdrawal syndrome. Nausea, vomiting, dizziness, agitation, anxiety, and headache are most common features of withdrawal if treatment stopped abruptly or if dose reduced markedly; dose should be reduced over several weeks. Drug action Drug action For mirtazapine Mirtazapine is a presynaptic alpha 2 -adrenoreceptor antagonist which increases central noradrenergic and serotonergic neurotransmission. Adult Initially 15—30 mg once daily for 2—4 weeks, dose to be taken at bedtime, then adjusted according to response to up to 45 mg once daily, dose to be taken at bedtime, alternatively up to 45 mg daily in 2 divided doses.

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I was under a great deal of stress and pressure over a period due to work and life in general, the outcome anxiety and endless nights with little or no sleep. The resultant peace and calm after an initial 'down' was amazing. I sleep like a baby and am back to my old laid back self without any loss of energy or clarity of mind. It will stack on the weight if you're not careful but so does lack of movement and comfort eating due to depression and anxiety. Watch your portion size and exercise and you'll be fine. For the past 5 years I have battled clinical depression.


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