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Inclusion: regular cycles, severe primary dysmenorrhoea, good physical health Exclusion: use of IUD or OCP, asthma, hepatic or renal disease Age: 16 to 31, mean Ketoprofen dose not mentioned, every 4 to 6 hours, no more than 4 per day, max. Diflunisal mg Naproxen mg Taken 4 times a day as needed, start at first sign of distress and continue as needed Duration: 4 cycles, each cycle randomised. Excluded: women with other pelvic pathology, gastric problems, pregnant, lactating, not using suitable contraception, drug sensitivities, serious illness, use of intrauterine device or oral contraceptives within past 6 months.
Not pregnant, using contraception. Etodolac mg taken every 12 hours Piroxicam 20 mg taken every 12 hours, first dose real, second placebo to maintain blinding Duration: 4 cycles, 1 cycle of each treatment. The 2 treatment groups were comparable at baseline. Placebo response based on 31 Primary outcome data available for all women 14 experimental, 31 placebo. Adverse effects data not solicited prospectively, no primary endpoints with regard to safety were defined.
Inclusion: women with primary dysmenorrhoea, complete physical and pelvic exams Exclusion: organic causes for dysmenorrhoea, cyclical irregularities Age: 17 to 38, experimental group mean Naproxen sodium mg initially, then mg every 6 hours as needed, max. Randomisation controlled by pharmaceutical company. Inclusion: women aged 18 to 35 years with primary dysmenorrhoea for previous 4 to 6 cycles, moderate to severe cramping routinely treated with oral medication.
Inclusion: primary dysmenorrhoea for at least 6 months, nulliparous Exclusion: gastric or duodenal ulcers, history of intolerance to NSAIDs Age: 14 to 33 years Location: Italy. Rescue medication paracetamol could be taken after 2 hours if necessary. Groups compared at baseline. Diclofenac sodium 50 to mg Naproxen to mg Duration: 2 cycles, 1 of each treatment.
Sections without translation will be in English. Inclusion: primary dysmenorrhoea Exclusion: secondary dysmenorrhoea, contraindications to indomethacin therapy Age: average 21, range 16 to 23 Parity: mostly nulligravidae Location: USA. Indomethacin 25 mg, 3 times daily, from 2 days prior to menses to 1 day after symptoms usually end Placebo Duration: 2 cycles control establish a baseline, 4 cycles treatment.
Results for both doses of fenoprofen mg and mg have been pooled for adverse effects data. Inclusion: primary dysmenorrhoea, medical and gynaecological exam Exclusion: pelvic abnormality, history of dyspepsia or peptic ulceration, use of OCP Age: 15 to 42, mean Inclusion: primary dysmenorrhoea, women aged 18 to 26 Exclusion: known gynaecological disease or abnormalities; history of peptic ulceration; gastrointestinal, haemorrhage, kidney or liver dysfunction; irregular cycles; IUD or OCP use; wish to get pregnant Location: UK.
Ibuprofen mg Paracetamol mg 2 capsules, taken 3 times a day, 24 hours prior to pain for a total of 4 days Duration: 2 cycles, 1 per treatment. Only GI adverse effects recorded as such other adverse effects classified as dysmenorrhoea symptoms. Inclusion: women with severe primary dysmenorrhoea, physical and pelvic exam Exclusion: women with major cycle irregularities, taking hormonal contraceptives, organic causes of dysmenorrhoea, women with gastrointestinal disorders or allergies to acetylsalicylates Age: 18 to 40, experimental mean 25 1.
Inclusion: primary dysmenorrhoea Exclusion: menstrual irregularities; history peptic ulcer, renal or blood disorders; pregnant; use of other medicines for condition Age: 17 to 33, mean Piroxicam 20 mg, placebo 2 tablets per day for 2 days, then 1 tablet per day until symptoms or menses subsided Duration: 4 cycles per participant, cycles in total. Inclusion: healthy women who required analgesia in the last 6 months because of menstrual cramps, regular menstrual cycles Exclusion: other gynaecological disorders, malignancy, renal, cardiac, haematological or gastrointestinal disease, use of sedatives or muscle relaxants within 48 hours of expected menstrual period, pregnancy all had pregnancy test Age: nimesulide group Nimesulide mg Diclofenac 50 mg Up to 3 tablets per day according to need, for the first 3 days of menstrual cycle Duration: 2 cycles Double dummy technique: active drug accompanied by placebo resembling alternative treatment.
Mefenamic acid mg, 4 times daily at onset of menses, max. Unclear whether adverse effects data prospectively solicited. Female university students with a history of primary dysmenorrhoea, starting shortly after menarche, who were nulliparous and not taking chronic medication including oral contraceptives for at least 6 months before the study. Inclusion: primary dysmenorrhoea for over 1 year, regular menstrual cycles, good emotional and physical health, ability to communicate feldene 600mg 12.5 intensity during study Exclusion: abnormal gynaecological pathology, gastrointestinal or osteoarticular abnormality, use of OCP within 1 month, bronchial asthma, urticaria or other allergic reaction to NSAIDs, renal or hepatic disease, concurrent medication with NSAIDs or corticosteroids Age: at least 18 Location: Argentina.
Inclusion: moderate to severe abdominal pain associated with primary dysmenorrhoea during a minimum of 4 of the last 6 menstrual cycles; good health with regular menses every 25 to 35 days; using an effective method of birth control or using OCP for at least 6 months; willing to abstain from alcohol during treatment phase of trial; pelvic and physical exam Exclusion: breastfeeding; IUD use; implant or ingestible contraceptive Norplant, Depo Provera ; history of hypersensitivity or adverse reactions to NSAIDs; history of chronic analgesic use; known cardiovascular, pulmonary, hepatic, gastrointestinal, renal, neurological, musculoskeletal, endocrine or metabolic disorders Age: over 15 Source: outpatients Location: multicentred, USA.
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