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Hydroxycarbamide, also known as hydroxyurea, is a medication used in sickle-cell disease, chronic myelogenous leukemia, cervical cancer, and polycythemia vera. Common side effects include bone marrow suppression, fevers, loss of appetite, psychiatric problems, shortness of breath, and headaches. It is believed to work by blocking the making of DNA. Hydroxycarbamide was approved for medical use in the United States in Due to its negative effect on the bone marrow, regular monitoring of the full blood count is vital, as well as early response to possible infections.

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