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Ondansetron is used orally or IV for the prevention of nausea and vomiting associated with emetogenic cancer chemotherapy. The drug is used IV with initial and repeat courses of emetogenic cancer chemotherapy, including high-dose cisplatin therapy. Ondansetron also is used orally with initial and repeat courses of moderately emetogenic cancer chemotherapy. The drug has been used effectively for the prevention of chemotherapy-induced emesis in patients receiving cisplatin alone or in combination with other antineoplastic agents and in those receiving other antineoplastic regimens e. To prevent chemotherapy-induced nausea and vomiting associated with highly emetogenic chemotherapy regimens including an anthracycline plus cyclophosphamide, the American Society of Clinical Oncology ASCO currently recommends a 3-drug antiemetic regimen consisting of a neurokinin-1 NK 1 receptor antagonist e. ASCO states that the oral, fixed-combination of netupitant and palonosetron plus dexamethasone is an additional antiemetic treatment option in this setting. For patients receiving moderately emetogenic chemotherapy regimens, ASCO recommends a 2-drug antiemetic regimen preferably consisting of palonosetron and dexamethasone.

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