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The drug is also used to treat severe rheumatoid arthritis, psoriasis, ulcerative colitis, and Crohn's disease. Azathioprine carries a black-box warning because it may increase your risk of developing certain cancers such as lymphoma, leukemia, and skin cancer. However, if you have a kidney transplant, you may be at a higher risk for developing cancer even if you don't take azathioprine. Avoid unnecessary exposure to sunlight to decrease your risk of skin cancer while taking azathioprine. You should wear protective clothing, sunglasses, and sunscreen when outdoors.

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Chronic immunosuppression with Imuran, a purine antimetabolite increases risk of malignancy in humans. Physicians using this drug should be very familiar with this risk as well as with the mutagenic potential to both men and women and with possible hematologic toxicities. It is an imidazolyl derivative of 6-mercaptopurine and many of its biological effects are similar to those of the parent compound. Azathioprine is stable in solution at neutral or acid pH but hydrolysis to mercaptopurine occurs in excess sodium hydroxide 0. Because of extensive metabolism, only a fraction of the radioactivity is present as azathioprine. Blood levels are of little predictive value for therapy since the magnitude and duration of clinical effects correlate with thiopurine nucleotide levels in tissues rather than with plasma drug levels. Azathioprine is metabolized to 6-mercaptopurine 6-MP. Both compounds are rapidly eliminated from blood and are oxidized or methylated in erythrocytes and liver; no azathioprine or mercaptopurine is detectable in urine after 8 hours. TPMT activity correlates inversely with 6-TGN levels in erythrocytes and presumably other hematopoietic tissues, since these cells have negligible xanthine oxidase involved in the other inactivation pathway activities.

Imuran 50 MG Tablet acts as an immuno-suppressant drug, which is used to treat ulcerative colitis, rheumatoid arthritis, Crohn's disease, and in kidney transplants to prevent the rejection of a new kidney. Do not use this medicine if you are allergic to any ingredient in Imuran 50 MG Tablet; if you are pregnant, if you have used alkylating agents in the past, or you are currently taking febuxostat or mercaptopurine. Dosage is as directed by your doctor, usually once or twice daily. The dosage is based on your weight, medical condition and response to treatment. If you increase your dose or use this drug more often or for longer than prescribed then you may increase the risk of it's side-effects. Uses and effects of the medicine may vary from person to person.

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Azathioprine 50 mg should be taken orally at about the same time each day, either with or without food. Most common singulair cost australia effects of Azathioprine include dizziness, diarrhea, fatigue, skin rashes, hair loss, acute pancreatitis, nausea, and vomiting. Yes, it is approved by the Food and Drug Administration FDA for use in kidney transplantation from human donors, and for rheumatoid arthritis. Azathioprine is a steroid-sparing agent or immunosuppression medicine. Azathioprine keeps the dose of steroids at a minimum level and eventually stops the use of steroids. Imuran is the brand name under which Azathioprine is sold.

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The dosage is prescribed by the consulting doctor and should be about mg of the active substance per 1 kg of weight per day in adults and children. Do not exceed the dosage of 3 mg of the order imuran 50 per 1 kg of weight per day. Do not use for pregnant and lactating women. Use with caution in patients with renal and hepatic insufficiency. When used together with allopurinol, oxypurinol or thiopurinol, the dosage should be reduced by 4 times.

Each attack worsens patients' disability. Considering that the disease can be disabling for orders imuran 50, the maintenance treatment should be applied in addition to treatment of acute attacks, in order to prevent future recurrences. Acute attacks are usually treated with high doses of intravenous corticosteroids. Plasmapheresis is also used when patients fail to response to corticosteroids. B lymphocyte inhibitors are used as the maintenance therapy in these patients. First line therapeutic medications include azathioprine and rituximab which are being recommended for long term therapy and second line medications include methotrexate and mycophenolate mofetil.

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