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The drug comes as a delayed-release capsule that you swallow.
- Duloxetine, sold under the brand name Cymbalta among others, 1 is a medication used to treat major depressive disorder, generalized anxiety disorder, fibromyalgia, neuropathic pain and central sensitization.
- Cymbalta duloxetine is a member of the serotonin-norepinephrine reuptake inhibitors drug class and is commonly used for Anxiety, Back Pain, Chronic Pain, and others.
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For some patients, consider starting at 30 mg qDay for 1 week, to allow patients to adjust to medication before increasing to 60 mg qDay. Treatment of chronic musculoskeletal pain, including discomfort from osteoarthritis and chronic lower back pain. Before initiating treatment, screen for a personal or family history of bipolar disorder, mania, or hypomania. Cardiovascular: Hypertensive crisis, supraventricular arrhythmia, myocardial infarction, tachycardia, Takotsubo cardiomyopathy. Gastrointestinal: Colitis microscopic or unspecified, cutaneous vasculitis sometimes associated with systemic involvement, acute pancreatitis. Suicidality; monitor for clinical worsening and suicide risk, especially in children, adolescents and young adults years during early phases of treatment and alterations in dosage see Black Box Warnings.

The starting and recommended maintenance dose is 60 mg once daily with or without food. Dosages above 60 mg once daily, up to a maximum dose of mg per day have been evaluated from a safety perspective in clinical trials. However, there is no clinical evidence suggesting that patients not responding to the initial recommended dose may benefit from dose up-titrations. After consolidation of the antidepressive response, it is recommended to continue treatment for several months, in order to avoid relapse. The recommended starting norvasc 2.5 mg tablets in patients with generalised anxiety disorder is 30 mg once daily with or without food. In patients with insufficient response the dose should be increased to 60 mg, which is the usual maintenance dose in most patients.
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Discontinuing an antidepressant medication usually involves reducing your dose in increments, allowing two to six weeks or longer between dose reductions. Your clinician can instruct you in tapering your dose and prescribe the appropriate dosage pills. In some cases, you can use a pill cutter to create smaller-dose pills, though be sure to check with your clinician or pharmacist to find out if your antidepressant can be cut. Your tapering schedule will depend on which antidepressant you're taking, how long you've been taking it, your current dose, and any symptoms you had during previous medication changes. However, depending on how you respond to each dose reduction, you may want to taper more gradually using smaller dose reductions, longer intervals between dose reductions, or both.
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It also helps treat nerve pain associated with diabetic peripheral neuropathy. It works by helping balance natural substances in the brain that maintain mental balance and pain signals.
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