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Desloratadine trade names Clarinex and Aerius is a tricyclic H 1 inverse agonist that is used to treat allergies. It is an active metabolite of loratadine. It was patented in and came into medical use in Desloratadine is used to treat allergic rhinitis, nasal congestion and chronic idiopathic urticaria hives. An emerging indication for desloratadine is in the treatment of acne, as an inexpensive adjuvant to isotretinoin and possibly as maintenance therapy or monotherapy. The most common side-effects are fatigue 1. Co-administration with erythromycin, ketoconazole, azithromycin, fluoxetine or cimetidine resulted in elevated blood plasma concentrations of desloratadine and its metabolite 3-hydroxydesloratadine in studies. Desloratadine is a selective H 1 - antihistamine which functions as an inverse agonist at the histamine H 1 receptor.

In February, Clarinex tablets were additionally approved for the clarinex desloratadine 5mg tablet of perennial allergic rhinitis PAR and for symptomatic relief of chronic idiopathic urticaria CIU in adults and children over 12 years old. Clarinex is a once-daily non-sedating antihistamine that provides 24 hour relief. An estimated 45 million Americans are affected by allergies. AR symptoms impact daily functioning at work, school and during leisure time, resulting in millions of absentee days each year. Urticaria is characterized by itchy, swollen welts on the skin. EU Clinical Trials Privacy.

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The new treatment option addresses an important need for allergy sufferers, who indicate that nasal congestion is the most bothersome symptom of allergic rhinitis. In both 2-week randomized, parallel group trials, the antihistaminic efficacy of CLARINEX-D 12 HOUR, when examining symptoms of allergic rhinitis excluding nasal congestion, was significantly greater than that of pseudoephedrine alone during the treatment period. Seasonal allergies affect an estimated 36 million people in the U. Symptoms, which include sneezing, runny nose, congestion, itchy throat, or itchy and watery eyes, can have a significant impact on everyday activities at work, school and leisure time. CLARINEX Tablet side effects in patients 12 clarinex desloratadine 5mg tablets of age and older with seasonal and year-round allergies were similar to placebo and included sore throat, dry mouth and fatigue. Tablet side effects in patients 12 years of age and older with ongoing itching and rash from hives of unknown cause were headache, nausea and fatigue.

What is desloratadine, and how does it work mechanism of action? It is used to treat the symptoms caused by histamine. Histamine is a chemical that is responsible for many of the signs and symptoms of allergic reactions, for example, swelling of the lining of the nose, sneezing, and itchy eyes. Histamine is released from histamine-storing cells mast cells and then attaches to other cells that abilify 15 mg tablet receptors for histamine. The attachment of the histamine to the receptors causes the cells to be activated, releasing other chemicals which produce the effects that we associate with allergy.

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According to the manufacturer, the nonsedating antihistamines can be dosed up to a maximum daily clarinex desloratadine 5mg tablet indicated below. Drug Facts and Comparisons on-line. Clinical Pharmacology Internet database. Safety and tolerability of fexofenadine for the treatment of allergic rhinitis in children 2 to 5 years old. Ann Allergy Asthma Immunol ;

It also contains granulated sugar, natural and artificial flavor for bubble gum, and FDC Yellow 6 dye. Desloratadine is a white to off-white powder that is slightly soluble in clarinex desloratadine 5mg tablet, but very soluble in ethanol and propylene glycol. CLARINEX is indicated for the relief of the nasal and non-nasal symptoms of perennial allergic rhinitis in patients 6 months of age and older. CLARINEX is indicated for the symptomatic relief of pruritus, reduction in the number of hives, and size of hives, in patients with chronic idiopathic urticaria 6 months of age and older. Tablet disintegration occurs rapidly. Administer with or without water.

Desloratadine is available as the brand-name drug Clarinex. Desloratadine oral tablet is used to treat nasal and non-nasal symptoms of seasonal and perennial allergic rhinitis allergies. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. This helps relieve symptoms of allergic rhinitis.