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Bupropion exerts its pharmacological effects by weakly inhibiting the enzymes involved in the uptake of the neurotransmitters norepinephrine and dopamine from the synaptic cleft, therefore prolonging their duration of action within the neuronal synapse and the downstream effects of these neurotransmitters. When used as an aid to smoking cessation, bupropion is thought to confer its anti-craving and anti-withdrawal effects by inhibiting dopamine reuptake, which is thought to be involved in the reward pathways associated with nicotine, and through the antagonism of the nicotinic acetylcholinergic receptor. Bupropion is sometimes used as an add-on agent to first-line treatments of depression such as selective serotonin reuptake inhibitor SSRI medications when there is a treatment-failure or only partial response. This includes the hypothalamus, which is involved in appetite regulation, and the mesolimbic dopamine circuit, which is involved in reward pathways. A governmentally-recognized ID which uniquely identifies the product anafranil 250 mg its regulatory market. Bupropion is indicated for the treatment of major depressive disorder MDD, seasonal affective disorder SAD, and as an aid to smoking cessation.
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Bupropion belongs to the family of medications known as antidepressants. It is used to treat depression. It works by affecting the balance of chemicals that occur naturally in the brain. For the treatment of depression, the full effects of the medication may not be seen until after several weeks of treatment. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
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Please save your reference number: for further communication. How the modulation of dopamine and noradrenaline treat MDD and SAD is not well understood by clinicians and researchers.
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