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It causes increased amounts of sodium and water to be excreted, while potassium loss is minimized. Spironolactone acts both as a diuretic and as an antihypertensive drug by this mechanism. It may be given alone or with other diuretic agents which act more proximally in the renal tubule. Blood and lymphatic system disorders: Leukopenia including agranulocytosis, thrombocytopenia, anemia.

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Aldactone's main mechanism of action involves antagonizing the hormone aldosterone. Aldactone medication accomplishes this by competitively engaging receptors involved with the exchange of the electrolytes potassium and sodium in a part of the kidney known as the distal convoluted tubule. In this capacity, aldosterone reduces the amount of potassium lost from the body. Aldactone also helps in cases of hyperaldosteronism, making it useful as a treatment for essential hypertension.

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