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Conclusions Among patients with high on-treatment reactivity after PCI with drug-eluting stents, the use of high-dose clopidogrel compared with standard-dose clopidogrel did not reduce the incidence of death from cardiovascular causes, nonfatal myocardial infarction, or stent thrombosis. Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity.
All deaths were considered cardiovascular unless an unequivocal noncardiovascular cause could be established; hemorrhagic deaths were also considered to be cardiovascular. The baseline characteristics of patients with and without high on-treatment reactivity differed greatly, as noted in previous, smaller studies. Pilot study of the antiplatelet effect of increased clopidogrel maintenance dosing and its relationship to CYP2C19 genotype in patients with high on-treatment reactivity.
Several studies have suggested that patients with high on-treatment platelet reactivity while receiving clopidogrel are at an increased risk of cardiovascular events after PCI, including stent thrombosis. The risk of determining risk with multivariable models. Race and ethnicity were self-identified. Predictors of heightened platelet reactivity despite dual-antiplatelet therapy in patients undergoing percutaneous coronary intervention.
However, undertreatment may explain our findings because high-dose clopidogrel resulted in only a modest reduction in the level of on-treatment reactivity and in the rate of high on-treatment reactivity compared with standard-dose clopidogrel. We found that treatment with a 6-month post-PCI regimen of high-dose clopidogrel did not appear to be accompanied by an excess of severe or moderate bleeding events or intracranial hemorrhage compared with a standard-dose regimen.
Pharmacodynamic studies have demonstrated wide interindividual variability in the platelet inhibitory response to clopidogrel, and observational studies have linked a poor pharmacodynamic response to cardiovascular events after PCI. Several potential mechanisms may explain the lack of a beneficial treatment effect with high-dose clopidogrel. Impact of platelet reactivity after clopidogrel administration on drug-eluting stent thrombosis.
A permuted block design was used to select these patients over the course of the trial. Landmark analysis at 30 days also demonstrated a greater, but not significant, risk of events in patients with high on-treatment reactivity 17 1. Variability in individual responsiveness to clopidogrel: clinical implications, management, and future perspectives. Specialized software developed for the trial encrypted the platelet function results to maintain double blinding.
Evaluation of individualized clopidogrel therapy after drug-eluting stent implantation in patients with high residual platelet reactivity: design and plavix purchase of the GRAVITAS trial. Clopidogrel exposure prior to enrollment was similar across all 3 treatment groups. The sponsor coordinated the data management with a contract research organization Synteract, Carlsbad, California. Objective To evaluate the effect of high-dose compared with standard-dose clopidogrel in patients with high on-treatment platelet reactivity after PCI.
Main Outcome Measures The primary end point was the 6-month incidence of death from cardiovascular causes, nonfatal myocardial infarction, or stent thrombosis. The possibility that on-treatment platelet reactivity is not a modifiable risk factor for thrombotic events after PCI cannot be excluded. The principal secondary analysis was an observational comparison of the rate of the primary efficacy variable among the patients with and without high on-treatment reactivity treated with standard-dose clopidogrel.
The treatment groups were generally well balanced with regard to baseline demographic, clinical, and procedural characteristics Table 1.

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Authored by Dr. Sheila R Jungmeyer, DDS