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Indomethacin can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease.
- Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug NSAID with anti-inflammatory, analgesic, and antipyretic properties.
- It works by reducing pain, swelling, and inflammation.
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These can occur without warning and can be fatal. This risk may increase if you take indomethacin for a prolonged period of time. You also may be at higher risk if you have a history of heart disease or high blood pressure. Taking indomethacin may trigger high blood pressure or make it worse, and high blood pressure is a risk factor for stroke and heart attack. Indomethacin and other NSAIDs may cause ulcers, perforations, and sudden bleeding in your stomach or intestine known as gastrointestinal, or GI, bleeding. This can occur at any time during treatment. You may be at higher risk for GI bleeding if you are elderly, drink a lot of alcohol, smoke, are in poor health, or take any blood-thinning medication.
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However, your doctor or pharmacist may have suggested a different schedule that is more appropriate for you. Depending on the treated condition, it may be used regularly or only as needed. Do not use more of this product, or more often, than prescribed. This medication may irritate the stomach, and should be taken with food. It is best to avoid coffee, spicy food or alcohol. Each person may react differently to a treatment. If you think this medication may be causing side effects including those described here, or others, talk to your doctor or pharmacist.
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Indomethacin is used to treat moderate to severe osteoarthritis, rheumatoid arthritis, gouty arthritis, or ankylosing spondylitis. Extended-release indomethacin should not be used to treat gouty arthritis. Indomethacin can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. If you are pregnant, you should not take indomethacin unless your doctor tells you to. Taking an NSAID during the last 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn baby and possible complications with your pregnancy.
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There was no significant difference between treatments in any of the secondary efficacy variables. Lumiracoxib indocin 50 mg as effective as indomethacin for treatment of acute gout and may have a better safety and tolerability profile. Although pain is the primary symptom of acute gout, optimal therapy is directed at controlling inflammation. However, colchicine is associated with a high rate of gastrointestinal GI side effects and it becomes less effective as the attack of gout persists 1, 3. Non-steroidal anti-inflammatory drugs NSAIDs have become standard therapy as they can suppress inflammation and provide analgesia 1, 4.

Indomethacin is a non-steroidal anti-inflammatory drug NSAID that exhibits, antipyretic and analgesic properties. Its mode of action, like that of other anti-inflammatory drugs, is not known. Contraindicated in patients with known hypersensitivity indocin 50 mg indomethacin or the excipients, in patients with active peptic ulceration, in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Also contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft CABG surgery. Suppositories are contraindicated in patients with a history of proctitis or recent rectal bleeding.
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This medicine can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use indomethacin. Seek emergency medical help if you have symptoms of heart or circulation problems, such as chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance. These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking indomethacin. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.
Indomethacin is a nonsteroidal anti-inflammatory drug NSAID that reduces fever, pain and inflammation. It is similar to ibuprofen Motrin and naproxen Naprosyn, Aleve. Indomethacin works by reducing the production of prostaglandins. Prostaglandins are chemicals that the body produces and which cause the fever and pain that are associated with inflammation. Indomethacin blocks the enzymes that make prostaglandins cyclooxygenase 1 and 2 and thereby reduces the levels of prostaglandins. As a result, fever, pain and inflammation are reduced.

Indomethacin 25mg Tablet SR. Jagsonpal Pharmaceuticals Ltd. Product introduction Indomethacin 25mg Tablet SR helps in relieving moderate pain and reducing fever. It effectively alleviates pain and inflammation in conditions like rheumatoid arthritis, osteoarthritis, gout, and ankylosing spondylitis. Indomethacin 25mg Tablet SR should be taken in the dose and duration as advised by your doctor. It should be taken with food or milk to prevent stomach upset.