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What is diltiazem, and how does it work mechanism of action? Diltiazem is a drug that is used for treating heart pain angina, high blood pressure, and abnormal heart rhythms. CCBs block the entry of calcium into muscle cells that make up the heart and that surround the arteries. It is the entry of calcium into these cells that causes the cells to contract, allowing the heart to pump blood, and the arteries to narrow. By blocking the entry of calcium, diltiazem decreases the force of contraction of the heart and its rate of contraction. It also relaxes the muscles surrounding the arteries, allowing the arteries to widen dilate.

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