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Effective prevention and treatment are needed to reduce these negative impacts. In addition, three non-graded consensus-based statements were adopted. Further studies are needed to address knowledge gaps regarding optimal therapies, the individual, community and global health risks of MDR acquisition, manipulation of the microbiome in prevention and treatment and the utility of laboratory testing in returning travelers with persistent diarrhea. Upon discovery that bacterial etiologies were a predominant cause, the debate surrounding appropriate management has been evolving and aims to balance safety and efficacy of antimicrobial therapy.

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