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International Breastfeeding Journal volume 18, Article number: 11 Cite this article. Domperidone is one of the most commonly utilised pharmacological galactagogues, with evidence of increasing use in clinical practice. However, the use of domperidone as a galactagogue remains controversial, with mixed evidence on safety and efficacy, leading to variable clinical practice recommendations. Domperidone use was significantly higher in women who were primiparous, gave birth preterm, delivered by caesarean minipress 2mg prazosin, had self-perceived low milk supply, and saw a lactation consultant. The median duration of use was six weeks interquartile range 3—16 weeks. More conclusive clinical trials are needed to determine the efficacy, as well as optimal dose and duration, of domperidone use.

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