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Subjects will undertake a 1-week screening period to provide baseline data and for assessment of eligibility. Study treatment will be applied in and around the anus, three times daily, for up to 8 weeks. Concomitant laxatives and stool softeners will be permitted, as needed, during the entire study period screening and treatment to ensure that constipation or passage of hard stools does not confound evaluation or improvement of the condition. Fibre supplements will be allowed but should be continued at the baseline level. A record of the number of times the subject has defaecated, laxative and analgesic usage will also be made as well as the number of applications of study treatment, any changes to concurrent medications and any Adverse Events AEs.

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