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A breast cancer patient from York says she is disgusted by a shortage of the drug she and hundreds of other women rely on to reduce the risk of the disease returning. Mother-of-two Marion Barclay, 45, said the situation became so serious last Friday, she faced the prospect of missing her daily dose of Arimidex tablets. Anastrozole is a competitive inhibitor of the cytochrome P monooxygenase isozyme known as CYP19 or aromatase.

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