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Dexamethasone has very high glucocorticoid activity and insignificant mineralocorticoid activity. Dexamethasone is used for the treatment of suspected bacterial meningitis, A but is not licensed for this indication. Dexamethasone is used to reduce peri- and neonatal morbidity and mortality in women with established preterm labour, planned preterm birth, or preterm prelabour rupture of membranes, A but is not licensed for this indication. See Corticosteroids, general use. The card includes a management summary for the emergency treatment of adrenal crisis and sick day dosing, and can be issued by any healthcare professional managing such patients.
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From: Comprehensive Clinical Psychology, Rachel Whelan, Christian C. Apfel, in Pharmacology and Physiology for Anesthesia, Studies in animal models suggest that dexamethasone acts on the glucocorticoid receptor-rich bilateral nucleus tractus solitarius i. In fact, aprepitant's inhibition of CYP 3A4 activity approximately doubles the plasma concentration of dexamethasone Figure
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