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Common side effects include dry mouth, constipation, loss of appetite, sleepiness, weight gain, sexual dysfunction, and trouble urinating. In a meta-analysis of various trials involving fluoxetine Prozac, fluvoxamine Luvox, and sertraline Zoloft to test their relative efficacies in treating OCD, clomipramine was found to be the most effective. Possible symptoms include: nausea, vomiting, abdominal pain, diarrhoea, insomnia, headache, nervousness, anxiety, dizziness and worsening of psychiatric status. There is also a potential pharmacokinetic interaction with quinidine due to the fact that clomipramine is metabolised by CYP2D6 in vivo, diuretics due to the potential for hypokalaemia low blood potassium to develop which increases the risk for QT interval prolongation and torsades de pointes, the selective serotonin reuptake inhibitors SSRIs; due to both potential additive serotonergic effects leading to serotonin syndrome and the potential for a pharmacokinetic interaction with the SSRIs that inhibit CYP2D6 while serotonin reuptake inhibition only is thought to be responsible for the effectiveness of clomipramine in the treatment of OCD. In accordance, while serotonin receptor antagonists like cyproheptadine and chlorpromazine are effective as antidotes against serotonin syndrome, clomipramine is nonetheless capable of inducing this syndrome. Clomipramine was developed by Geigy.

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This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. This product is available in multiple strengths and all strengths will be referred to throughout this leaflet What you need to know about Anafranil Your doctor has decided that you need this medicine to help treat your condition. This medicine has been prescribed for you. Never give it to someone else. It may not be the right medicine for them even if their symptoms seem to be the same as yours. If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

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Avoid; strong anticholinergic and sedative effects; may cause orthostatic hypotension Beers criteria. In children and young adults, risks must be weighed against the benefits of taking antidepressants. Patients should be monitored closely for changes in behavior, clinical worsening, and suicidal tendencies; this should be done during initial months of therapy and dosage adjustments. Worsening behavior and suicidal tendencies that are not part of the presenting symptoms may require discontinuation of therapy. Clinical worsening and suicide ideation may occur despite medication in adolescents and young adults yr.