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Fluoxetine is used in the treatment of major depressive disorder, obsessive-compulsive disorder, premenstrual dysphoric disorder, bulimia nervosa, and panic disorder with or without agoraphobia. In addition, fluoxetine has been used for the treatment of depression associated with bipolar disorder; obesity; anorexia nervosa; myoclonus; cataplexy; alcohol dependence; and premature ejaculation. Fluoxetine is used in the acute and maintenance treatment of major depressive disorder in adults and pediatric patients 8 years of age and older. A major depressive episode implies a prominent and relatively persistent depressed or dysphoric mood that usually interferes with daily functioning nearly every day for at least 2 weeks.

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A governmentally-recognized ID which uniquely identifies the product within its regulatory market. Fluoxetine is indicated for both acute and maintenance treatment of major depressive disorder, obsessive compulsive disorder, and bulimia nervosa; however, it is only indicated for acute treatment of panic disorder independent of whether agoraphobia is present. Fluoxetine blocks the serotonin reuptake transporter in the presynaptic terminal, which ultimately results in sustained levels of 5-hydroxytryptamine 5-HT in certain brain areas. The cheapest fluoxetine hypothesis of depression emerged in and linked depression with dysfunction of neurotransmitters such as noradrenaline and serotonin.

An antidepressant from the group of selective inhibitors of serotonin reverse capture. Fluoxetine is an antidepressant group of selective serotonin reuptake inhibitors.

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When community pharmacies cannot source a drug at or below the reimbursement price as set out in the Drug Tariff, the Department of Health and Social Care DHSC can introduce a price concession at the request of Community Pharmacy England. No additional endorsements are required for price concessions. Rolled over prices will be identified as such. Please include full details of the supplier and price paid for any products sourced above the Drug Tariff price. We will investigate the extent of the problem and, if appropriate, discuss the issue with DHSC.

This is a plain English summary of an original research article. Antidepressants are effective to treat moderate to severe depression in adults. Five antidepressants appear more effective and better tolerated than others.

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